HANG

Inflammation & Rehydration Protocol

Alcohol-related inflammation reduced, hydration and micronutrients restored.

Prickly pear extract (Opuntia ficus-indica) 800 mg

Electrolyte complex — Sodium 300 mg, Potassium 200 mg, Magnesium citrate 100 mg

High-dose B complex (benfotiamine and cofactors)

What it does

INFLAMMATION & REHYDRATION PROTOCOL

HANG acts before the event on the systemic inflammation induced by alcohol metabolites, and supports fluid, electrolyte and vitamin repletion afterwards — with ingredients supported by human RCTs, not by in vitro or murine studies alone.

The market bug

The hangover category is dominated by dihydromyricetin (DHM), a trending ingredient with aggressive marketing but supported almost exclusively by preclinical animal studies rather than robust human RCTs. Meanwhile the market ignores the most obvious and demonstrated mechanism: dehydration from alcohol-induced suppression of antidiuretic hormone, and the acute depletion of B vitamins and hepatic glutathione during ethanol metabolism.

Formula — actives per doseEFSA-compliant claims only

Mechanism

Among the anti-hangover ingredients currently on the market, the only one with a controlled human RCT published in a high-impact journal (Wiese et al., JAMA 2004): taken about 5 hours before alcohol consumption, it significantly reduced hangover symptom severity (nausea, dry mouth, loss of appetite) by roughly 50%, correlated with a reduction in C-reactive protein.

Effect

Timing is the distinctive part — this is taken before drinking, not the morning after. We position it as the pre-loading step of the protocol.

Why these ingredients

We built this backwards from the evidence, not from the trend. The one ingredient with a human RCT in a major journal goes first — and it only works if you take it before you go out. Everything else addresses the two mechanisms that are actually documented: ADH suppression and acute B-vitamin depletion.

How it works

Two-step protocol: pre-load before the event for the anti-inflammatory layer; repletion afterwards for fluid, electrolytes and B vitamins.

Transparency note

We deliberately exclude dihydromyricetin (DHM), currently very fashionable in the sector: the supporting evidence is almost entirely preclinical (murine models) and does not meet our human-evidence standard. Final formulation of this SKU is still being locked with the manufacturer.

How to use

Two capsules with water, preferably before alcohol consumption or before sleep.

Timing — As needed

Who it's for